Nanopartículas para liberar principios activos en la curación de heridas diabéticas: una revisión de la literatura
DOI:
https://doi.org/10.20435/multi.v30i74.4564Palabras clave:
nanopartículas, liberação tópica, feridas diabéticas, úlceras diabéticas, cicatrizaçãoResumen
La diabetes mellitus (DM) es una enfermedad crónica que afecta a millones de personas en todo el mundo, reduciendo la calidad de vida y causando complicaciones graves, como las heridas diabéticas (HDs). Estas heridas, difíciles de curar, son propensas a infecciones, llevando a amputaciones de extremidades inferiores y altos costos de tratamiento. Las opciones terapéuticas actuales para las HD son limitadas, subrayando la necesidad de nuevos enfoques. Las nanopartículas (NPs), una innovación en Nanotecnología, muestran un gran potencial en la curación de HD. Estudios científicos indican que las NPs pueden mejorar la liberación de agentes cicatrizantes, aumentar su solubilidad y estabilidad y mejorar la penetración en la piel, aumentando la eficacia del tratamiento y reduciendo los efectos adversos. Una revisión bibliográfica de 28 artículos en los últimos 10 años analizó la liberación de agentes activos, actividad antimicrobiana, seguridad y eficacia de las NPs en modelos in vitro e in vivo, mostrando que pueden optimizar la terapia de curación de HDs y reducir complicaciones en pacientes diabéticos.
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Derechos de autor 2024 Maria Bernadete Pierre, Adrielle Rodrigues da Silva
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