Nanoparticles for releasing active ingredients in the healing of diabetic wounds: a literature review
DOI:
https://doi.org/10.20435/multi.v30i74.4564Keywords:
nanoparticles, topical delivery, diabetic wounds, diabetic ulcers, healingAbstract
Diabetes mellitus (DM) is a chronic disease that affects millions of people worldwide, reducing quality of life and causing severe complications, such as diabetic wounds (DWs). These wounds, which are difficult to heal, are prone to infections, often leading to lower limb amputations and high treatment costs. Current therapeutic options for DWs are limited, highlighting the need for new approaches. Nanoparticles (NPs), an innovation in Nanotechnology, show promising potential in healing DWs. Scientific studies indicate that NPs can improve the release of healing agents, enhance their solubility and stability, and increase skin penetration, thus boosting treatment efficacy and reducing adverse effects. A literature review of 28 articles published in the last 10 years analyzed the release of active agents, antimicrobial activity, safety, and efficacy of NPs in in vitro and in vivo models, showing that NPs can optimize DWs healing therapy and reduce complications in diabetic patients.
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