Nanoparticles for releasing active ingredients in the healing of diabetic wounds: a literature review

Authors

DOI:

https://doi.org/10.20435/multi.v30i74.4564

Keywords:

nanoparticles, topical delivery, diabetic wounds, diabetic ulcers, healing

Abstract

Diabetes mellitus (DM) is a chronic disease that affects millions of people worldwide, reducing quality of life and causing severe complications, such as diabetic wounds (DWs). These wounds, which are difficult to heal, are prone to infections, often leading to lower limb amputations and high treatment costs. Current therapeutic options for DWs are limited, highlighting the need for new approaches. Nanoparticles (NPs), an innovation in Nanotechnology, show promising potential in healing DWs. Scientific studies indicate that NPs can improve the release of healing agents, enhance their solubility and stability, and increase skin penetration, thus boosting treatment efficacy and reducing adverse effects. A literature review of 28 articles published in the last 10 years analyzed the release of active agents, antimicrobial activity, safety, and efficacy of NPs in in vitro and in vivo models, showing that NPs can optimize DWs healing therapy and reduce complications in diabetic patients.

Author Biographies

Maria Bernadete Riemma Pierre, Universidade Federal do Rio de Janeiro (UFRJ)

Doutora e Mestre em Fármacos e Medicamentos pela Universidade de São Paulo (USP). Graduação em Farmácia Industrial pela Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo (USP). Professora associada da Universidade Federal do Rio de Janeiro (UFRJ).

Adrielle Rodrigues da Silva, Federal University of Rio de Janeiro

Graduação em Farmácia pela Universidade Federal do Rio de Janeiro (UFRJ). Subgerente farmacêutica responsável técnica em Drogaria.

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Published

2025-03-07

How to Cite

Bernadete Riemma Pierre, M., & Rodrigues da Silva, A. (2025). Nanoparticles for releasing active ingredients in the healing of diabetic wounds: a literature review. Multitemas, 30(74), 149–171. https://doi.org/10.20435/multi.v30i74.4564