Nanopartículas para liberação de ativos na cicatrização de feridas diabéticas: uma revisão da literatura
DOI:
https://doi.org/10.20435/multi.v30i74.4564Palavras-chave:
nanopartículas, liberação tópica, feridas diabéticas, úlceras diabéticas, cicatrizaçãoResumo
O diabetes mellitus (DM) é uma doença crônica que afeta milhões globalmente, reduzindo a qualidade de vida e causando complicações graves, como feridas diabéticas (FDs). Essas feridas, de difícil cicatrização, são suscetíveis a infecções, frequentemente levando a amputações de membros inferiores e altos custos de tratamento. As opções terapêuticas atuais para FDs são limitadas, destacando a necessidade de novas abordagens. Nanopartículas (NPs), uma inovação da Nanotecnologia, mostram potencial promissor na cicatrização de FDs. Estudos científicos indicam que NPs podem melhorar a liberação de ativos cicatrizantes, aumentar sua solubilidade e estabilidade e melhorar a penetração na pele, elevando a eficácia do tratamento e reduzindo efeitos adversos. Esta revisão bibliográfica de 28 artigos publicados nos últimos 10 anos analisou a liberação de ativos, atividade antimicrobiana, segurança e eficácia de NPs em modelos in vitro e in vivo, mostrando que NPs podem otimizar a terapia cicatrizante de FDs e reduzir complicações em pacientes diabéticos.
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