Chronic migraine and comorbidities: prevalence and pharmacological treatment

Authors

DOI:

https://doi.org/10.20435/multi.v30i74.4716

Keywords:

transtornos de enxaqueca, doenças, uso excessivo de medicamentos prescritos

Abstract

This article aims to evaluate disease and medication load in subjects with chronic migraine-a common and disabling condition that affects the quality of life being associated with reduction in labor and personal aspects.Most cases have several comorbidities and use polypharmacy.The study is a cross-sectional observational study, carried out in a hospital. The population was between 18 and 60 years,both genders,with diagnosis of chronic migraine following the International Classification of Headache Disorders, 2013.To analyze the burden of disease, we applied self-administered questionnaires and the Cumulative Illness Rating Scale(CIRS).Women were majority of the sample, with mean age of 43.9 years; 95.4% had another active disease-specially depressive and anxiety disorders;polypharmacy was observed in 58.6%.The most used drugs were anticonvulsants. Individuals with psychiatric conditions had the highest scores of cumulative illness.The study shows that chronic migraine has an extensive disease and medication load, and that the most relevant relates to the psychiatric domain,responsible for the most prevalent associated medical conditions and concomitant medication.

 

 

Author Biographies

Fernanda Rosa Willrich Gehlen, Universidade Federal do Paraná (UFPR)

Mestrado em Medicina Interna pela Universidade Federal do Paraná (UFPR). Especialista em Acupuntura Médica pela Associação Médica Brasileira. Residência em Infectologia pela UFPR. Graduação em Medicina pela Faculdade Evangélica do Paraná. Médica Infectologista da Secretaria Municipal de Saúde de Piraquara-PR.

Caroline Mensor Folchini, Universidade Federal do Paraná

Mestrado em Medicina Interna pela Universidade Federal do Paraná (UFPR). Graduação em Farmácia pela Instituto Federal do Paraná. Farmacêutica não cega em pesquisas com enfoque na neurologia no Instituto de Neurologia de Curitiba. Ministra aulas de farmacologia, Intro. Ciências Farmacêuticas e Bases Farmacêuticas na Unicesumar.

Pedro André Kowacs, Instituto de Neurologia de Curitiba

Mestrado em Medicina Interna pela Universidade Federal do Paraná (UFPR). Graduação em Medicina pela Fundação Universidade Federal de Ciências da Saúde de Porto Alegre.Residência em Neurologia pela Pontifícia Universidade Católica do Rio Grande do Sul.  Coordenador do Setor de Cefaleias e Dor do Serviço de Neurologia do Hospital de Clínicas da UFPR.

Viviane de Hiroki Flumignan Zétola, Universidade Federal do Paraná

Doutora em Neurologia pela Universidade de São Paulo (USP). Mestre em Medicina Interna pela Universidade Federal do Paraná (UFPR). Graduada em Medicina pela UFPR. Coordenadora do Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde da UFPR. Atualmente conduz 6 pesquisas clínicas na área de tratamento emergencial e prevenção secundaria da Doença Cerebrovascular.

References

AILANI, J.; BURCH, R. C.; ROBBINS, M. S. The board of directors of the American Headache Society. The American Headache Society Statment: update on integrating nem migraine treatments into clinical practice. Headache, [S. l.], v. 61, n. 7, p. 1021-1039, 2021.

BURCH, R. C.; BUSE, D. C.; LIPTON, R. B. Migraine: epidemiology, burden, and comorbidity. Neurol Clin., [S. l.], v. 37, n. 4, p. 631-649, 2019.

CÁMARA-LEMARROY, C. R.; RODRIGUEZ-GUTIERREZ R.; MONREAL-ROBLES R.; MARFIL-RIVERA A. Gastrointestinal disorders associated with migraine: A comprehensive review. World J Gastroenterol, [S. l.], 2016; v. 22, n. 36, p. 8149-8160, 2016.

CUCIUREANU, D. L.; BISTRICEANU, C. E.; VULPOI G.-A.; CUCIUREANU T.; ANTOCHI, F.; ROCEANU, A.-M. Migraine comorbidities. Life, [S. l.], v. 14, n. 1, 2024.

D'AMICO, D.; SANSONE, E.; GRAZZI, L.; GIOVANNETTI, A. M.; LEONARDI, M.; SCHIAVOLIN, S.; RAGGI, A. Multimorbidity in patients with chronic migraine and medication overuse headache. Acta Neurol Scand., [S. l.], v. 138, n. 6, p. 515-522, 2018.

GBD. Occupational Risk Factors Collaborators. Global and regional burden of disease and injury in 2016 arising from occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016. Occup Environ Med., [S. l.], v. 77, n. 3, p. 133-141, 2020.

HEADACHE CLASSIFICATION COMMITTEE OF THE INTERNATIONAL HEADACHE SOCIETY [IHS]. The International Classification of Headache Disorders, 3rd edition. Cephalalgia, [S. l.], v. 38, n. 1, p. 1-211, 2018.

HOVAGUIMIAN, A.; ROTH, J. Management of chronic migraine. BMJ, [S. l.], p. 379, 2022

JEYAGURUNATHAN, A.; ABDIN E.; VAINGANKAR, J. A.; CHUA, B. Y.; SHAFIE, S.; CHANG, S. H. S.; JAMES L.; TAN, K. B.; BASU, S.; CHONG, S. A.; SUBRAMANIAM, M. Prevalence and comorbidity of migraine headache: results from the Singapore Mental Health Study 2016. Soc Psychiatry Psychiatr Epidemiol., [S. l.], v. 55, n. 1, p. 33-43, 2020.

MILLER, M. D.; TOWERS, A. A manual of guidelines for scoring the Cumulative Illness Rating Scale for Geriatrics (CIRS-G). Pittsburg: University of Pittsburgh, 1991. p. 2-31

PERES, M. F. P.; QUEIROZ, L. P.; ROCHA-FILHO, P. S.; SARMENTO, E. M. Migraine: a major debilitating chronic non-communicable disease in Brazil, evidence from two national surveys. The Journal of Headache and Pain, [S. l.], v. 20, n. 85, 2019.

QUEIROZ, L. P.; SILVA JUNIOR, A. A. The prevalence and impact of headache in Brazil. Headache, [S. l.], v. 55, suppl. 1, p. 32-38, 2015.

SCHER, A. I.; WANG, S. J.; KATSARAVA, Z.; BUSE, D. C.; FANNING, K. M.; ADAMS, A. M.; LIPTON, R. B. Epidemiology of migraine in men: Results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study. Cephalalgia, [S. l.], v. 39, n. 2, p. 296-305, 2019.

WEATHERALL, M. W. The diagnosis and treatment of chronic migraine. Ther Adv Chronic Dis., [S. l.], v. 6, n. 3, p. 115-123, may 2015.

YANG, C. P.; WANG, S. J. Sleep in patients with chronic migraine. Curr Pain Headache Rep., [S. l.], v. 21, n. 9, p. 39, 2017.

Downloads

Published

2025-03-07

How to Cite

Rosa Willrich Gehlen, F., Mensor Folchini, C., Kowacs, P. A., & de Hiroki Flumignan Zétola, V. (2025). Chronic migraine and comorbidities: prevalence and pharmacological treatment. Multitemas, 30(74), 189–201. https://doi.org/10.20435/multi.v30i74.4716